Endocrine Abstracts

Thyroid hormones (THs) play a critical role in the regulation of growth and development in both animals and humans. They regulate metabolism primarily through actions in the brain, white fat, brown fat, skeletal muscle, liver and pancreas. Therefore, it is not surprising that since a long time scientists have been interested in measuring TH concentration in different tissues and to relate this value with possible dysfunctions. In general, TH levels are measured by immunoassay ...

Abstract: Inflammation plays a contributing role in the pathogenesis of several metabolic disorders, including type 2 diabetes and obesity. Intriguingly, obesogenic diets induce markers of hypothalamic inflammation and neuronal injury in both rodents and humans, suggesting that targeting inflammatory pathways in the hypothalamus might represent a novel strategy to control energy metabolism. Unfortunately, the majority of steroid-based anti-inflammatory drugs are fraught with a...